Micro Nano Bio Fluidics Unit

Micro Nano Bio Fluidics Unit

The unit's research is centered on the conception and comprehension of novel and fascinating micro/nanoscale interfacial phenomena. These phenomena could be caused by innate hydrodynamics or by extrinsic factors like acoustic fields. The core areas of investigation include acoustofluidics, droplets, and capillarity/wetting. The themes include the handling and manipulation of particles, droplets, biological cells, and fluid interfaces as well as the interaction of liquid interfaces with surfaces and deformable structures.

The unit is also dedicated to creating lab-on-chip (LOC) technology for healthcare applications. A LOC platform is being developed for in-situ and real-time rapid monitoring of gasotransmitters in blood for early diagnosis of sepsis. The unit has been working on microfluidics-based technologies for the isolation and detection of CTCs for early cancer diagnosis and prognosis, as well as tumor spheroids on chip for research and the development of cancer therapies. The focus of current research has been on understanding sperm cell dynamics and coming up with creative ways to sort sperm cells for sex selection in livestock and assisted reproductive technology.

We are funded by the Institutes of Eminence (IoE) scheme, Govt. of India.

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RECENT NEWS

The first Indian Conference on Micro nano fluidics (ICOM 2023) will be held at IIT Madras from Sep 29 to October 1, 2023.

See website- https://www.icom2023.in/

SELECTED RECENT PUBLICATIONS

  • Acoustic particle trapping driven by axial primary radiation force in shaped traps, L. Malik, A. Nath, S. Nandy, T. Laurell, and A. K. Sen, Physical Review E, 2022.

  • Reversible stream drop transition in a microfluidic coflow system via on demand exposure to acoustic standing waves, E.Hemachandran*, S.Z.Hoque*, T.Laurell, A.K.Sen*, Physical Review Letters, 2021. *equal contribution.

  • Evaporation-induced transport of a pure aqueous droplet by an aqueous mixture droplet, B. Majhy and A. K. Sen, Physics of Fluids, 2020.

  • 87. Cassie-Wenzel wetting transition on nanostructured superhydrophobic surfaces induced by surface acoustic waves, A. Sudeepthi, L. Yeo and A. K. Sen, Applied Physics Letters, 2020. Editor's picks article.

  • 88. Understanding of the role of dilution on evaporative deposition patterns of blood droplets over hydrophilic and hydrophobic substrates, R. Iqbal, A. Q. Shen and A. K. Sen, J Colloid & Interface Science, 2020.

  • Trapping and coalescence of diamagnetic aqueous droplets using negative magnetophoresis, S. K. Jain, U. Banerjee, and A. K. Sen, Langmuir, 2020.

  • Interparticle acoustic radiation force between a pair of spherical particles in a liquid exposed to a standing bulk acoustic wave, S. Z. Hoque and A. K. Sen, Physics of Fluids, 2020.

  • Understanding of the role of dilution on evaporative deposition patterns of blood droplets over hydrophilic and hydrophobic substrates, R. Iqbal, A. Q. Shen and A. K. Sen, J Colloid & Interface Science, 2020

  • Shape evolution of drops on surfaces of different wettability gradients, I. Chowdhury, P. S. Mahapatra, and A. K. Sen, Chemical Engineering Science, 2020.

  • Optomicrofluidic device for detection and isolation of drop encapsulated target cells in single-cell format, R. Gaikwad and A. K. Sen, Analyst, 2020.

     

  • Cross-stream migration of droplets in a confined shear-thinning viscoelastic flow: role of shear-thinning induced lift, S. Hazra, S. K. Mitra and A. K. Sen, Physics of Fluids, 2020.

     

  • Continuous electrical lysis of cancer cells in a microfluidic device with passivated interdigitated electrodes, K. Pandian*, P. Ajanth*, S. Z. Hoque, A. Sudeepthi, and A. K. Sen, Biomicrofluidics, 2020.

     

  • Buckling and snapping of a thin polymeric membrane exposed to a solvent drop, R. A. Samy, N. S. Satpathi, and A. K. Sen, EPL (Europhysics Letters), 2020..

     

  •  Attraction and Repulsion between Liquid Droplets over a Liquid-impregnated Surface, B. Majhy, S. K. Jain and A. K. Sen, Journal of Physical Chemistry Letters, 2020.

     

ANNOUNCEMENTS

  • Congratulations Dr. Ravindra Gaikwad for your new position as partner in Saber Biotech, Paris, France.

  • Congratulations to Dr. Utsab Banerjee and Dr. Butunath Majhy for successfully defending their theses and getting Post-Doctoral Fellowships at the University of Waterloo and Alberta, Canada, respectively.

  • Rameez Iqbal and Mr. Utsab Banerjee, PhD scholars of our Lab, received the Institute Research Award (IRA) on recognition of their PhD research work, Congratulations!

  • Rameez Iqbal has successfully defended his doctoral thesis, congratulations Dr. Rameez Iqbal!

  • Sudeepthi A. and Utsab Banerjee won Best Student Presentation Awards at the 7th International and 45th National Fluid Mechanics and Fluid Power (FMFP) conference held at IIT Bombay during 10 - 12, December 2018.

  • Dr. Ashis Kumar Sen received The SwarnaJayanti Fellowship Award 2017 - 2018 (Engineering Sciences), Dept. of Science & Technology, India.

  • PhD scholar Ravindra Gaikwad (and Dr. Ashis Kumar Sen as mentor) received the SITARE-Gandhian Young Technological Awards 2020.

  • Dr. Jayaprakash K S a PhD scholar from our lab joined ESPCI, Paris for a post-doc position.

     

  • Dr. Ashis Kumar Sen received the Young Faculty Recognition Award (YFRA) – 2017, IIT Madras.

     

  • Dr. Ashis Kumar Sen received the Institute Research & Development Awards (IRDA) – Early Career Level Award, IIT Madras - 2017.

     

  • Our work on capillary and acoustics based blood-plasma separation got selected for display in the Exhibition on Innovations in Medical Science and Bio Technology for Grassroots Applications on 09 March, 2017 at Rashtrapati Bhavan, New Delhi.
  • Our research work on “Capillary based blood-plasma separation” appeared in Hindu on 26 Sep 2016.
  • Dr. Ashis Kumar Sen received the Indian National Academy of Engineering (INAE) Young Engineer Award – 2013.
  • Dr. Ashis Kumar Sen received the Institute of Engineers India (IEI) Young Engineer Award – 2013.
  • Dr. Abhishek Raj, alumni (PhD scholar) of our lab is offered a regular faculty (Assistant Professor) position at IIT Patna.

FUNDING ACKNOWLEDGEMENT







Collaborators

  • Okinawa Institute of Science and Technology, Japan.
  • University of Waterloo, Canada.
  • Lund University, Sweden.
  • RMIT University, Australia.
  • Dr. Paul Ramesh, Cardiothoracic Surgeon, Apollo Hospitals, Chennai.
  • Dr. Anil Tarigopula, Pathologist, Apollo Hospitals, Chennai.
  • Prof. K M Muraleedharan, Department of Chemistry, IIT Madras.
  • Prof. Anil Prabhakar, Department of Electrical Engineering, IIT Madras.